When will this shit end?

[Bisque]

[zahidf]

Hmmm

Trump claims what we've gone through now won't be repeated. We might have some "embers" of corona in the second wave. He says he's spoken to "10 different people" and "not gonna be like it was." He also says "it might not come back at all."

Trump: If this virus comes back, it won't come back anywhere "near" the current level...but there could be a "mess" if there are "embers of corona coupled with the flu," which is "not gonna be pleasant"...but also not "what we've gone through," and we're more prepared now.

 

Toilet duck, is this scientifically correct?

 

Edited April 22, 2020 by zahidf

[zahidf]

Well

This paper looks very interesting.

The SARS-CoV-2 receptor-binding domain elicits a potent neutralizing response without antibody-dependent enhancement
https://www.biorxiv.org/content/10.1101/2020.04.10.036418v1
The SARS-coronavirus 2 (SARS-CoV-2) spike (S) protein mediates entry of SARS-CoV-2 into cells expressing the angiotensin-converting enzyme 2 (ACE2). The S protein engages ACE2 through its receptor-binding domain (RBD), an independently folded 197-amino acid fragment of the 1273-amino acid S-protein protomer. Antibodies to the RBD domain of SARS-CoV (SARS-CoV-1), a closely related coronavirus which emerged in 2002-2003, have been shown to potently neutralize SARS-CoV-1 S-protein-mediated entry, and the presence of anti-RBD antibodies correlates with neutralization in SARS-CoV-2 convalescent sera. Here we show that immunization with the SARS-CoV-2 RBD elicits a robust neutralizing antibody response in rodents, comparable to 100 µg/ml of ACE2-Ig, a potent SARS-CoV-2 entry inhibitor. Importantly, anti-sera from immunized animals did not mediate antibody-dependent enhancement (ADE) of S-protein-mediated entry under conditions in which Zika virus ADE was readily observed. These data suggest that an RBD-based vaccine for SARS-CoV-2 could be safe and effective.

Edited April 22, 2020 by zahidf

[squirrelarmy]

4 hours ago, Avalon_Fields said:

We can have 2 metre square painted areas throughout the pyramid field, only one person per square.

We’re going to have to up our fitness game for the crowd surfers. Throwing someone 2 metres is going to be a challenge 

[Yoghurt on a Stick]

1 hour ago, Bisque said:

Now, that is funny.

[Bisque]

8 minutes ago, Yoghurt on a Stick said:

Now, that is funny.

I wasn’t being sexist in any way.

[Yoghurt on a Stick]

1 hour ago, Bisque said:

I wasn’t being sexist in any way.

That's even more funny again - as well you know. I'd had you down as 'our' Far East specialist, but not one for savage wit. How wrong was I?

[Avalon_Fields]

12 hours ago, crazyfool1 said:

I need that much space for my crap dancing  

You’ll need 10 Sq metres for your pyramid hat!

[Crazyfool01]

12 minutes ago, Avalon_Fields said:

You’ll need 10 Sq metres for your pyramid hat!

I can walk into any field at the moment and have my own pyramid field  

[Superscally]

8 hours ago, zahidf said:

Hmmm

Trump claims what we've gone through now won't be repeated. We might have some "embers" of corona in the second wave. He says he's spoken to "10 different people" and "not gonna be like it was." He also says "it might not come back at all."

Trump: If this virus comes back, it won't come back anywhere "near" the current level...but there could be a "mess" if there are "embers of corona coupled with the flu," which is "not gonna be pleasant"...but also not "what we've gone through," and we're more prepared now.

 

Toilet duck, is this scientifically correct?

 

It may be, but unlikely. It's an optimistic theory.

[HalfAnIdiot]

9 hours ago, Yoghurt on a Stick said:

Your post above has been pointed out to me. I have also been informed not to worry because you are evidently a twat.

Make of that what you will.

 

 

 

Unnecessary, you obviously had a wobble back there and weren't making much sense (by your own admission). Let's try to be nice to each other please, no one knows the state of the person they are addressing on here. 

Edited April 23, 2020 by HalfAnIdiot

[Superscally]

15 hours ago, efcfanwirral said:

Ha I'm very similar. Cant believe how much beer I've got through these past few weeks. Sitting in the garden reading in the sun with a beer about this time has become a daily ritual now. Not complaining at all! 

My only problem is sleep patterns - I'm going to bed and getting up later and later...

Free delivery to the Wirral.  I got mine yesterday. 

https://www.blacklodgebrewing.co.uk/store

...and they say Liverpool and Everton don't get on any more... Bollocks. 😎

[Deaf Nobby Burton]

9 hours ago, zahidf said:

Hmmm

Trump claims what we've gone through now won't be repeated. We might have some "embers" of corona in the second wave. He says he's spoken to "10 different people" and "not gonna be like it was." He also says "it might not come back at all."

Trump: If this virus comes back, it won't come back anywhere "near" the current level...but there could be a "mess" if there are "embers of corona coupled with the flu," which is "not gonna be pleasant"...but also not "what we've gone through," and we're more prepared now.

 

Toilet duck, is this scientifically correct?

 

I think he’s right, a bit. The German antibody test from a few weeks back showed that around around 15% of Germans had already had it. So coupled with better awareness and social distancing a second wave couldn’t really be as bad, it wouldn’t really be possible. That said it could still likely be quite bad, and to say it will just be ‘embers’ I don’t think has any real scientific basis.

[parsonjack]

Probably opening myself for a wave of down votes but after Whitty's somewhat downbeat forecast last night I've woken today with growing doubts that, given the lead time to plan/build etc, G2021 will be possible 😕

Sorry. 

[zahidf]

Interesting.

 

[zahidf]

13 minutes ago, parsonjack said:

Probably opening myself for a wave of down votes but after Whitty's somewhat downbeat forecast last night I've woken today with growing doubts that, given the lead time to plan/build etc, G2021 will be possible 😕

Sorry. 

Too early to say. And I dont think that sort of speculation is helpful tbh

[jparx]

Must say I'm hugely relieved that Trump PhD has confirmed we won't have a big second peak. What a load off my mind! Back to work I go.

[Crazyfool01]

17 minutes ago, parsonjack said:

Probably opening myself for a wave of down votes but after Whitty's somewhat downbeat forecast last night I've woken today with growing doubts that, given the lead time to plan/build etc, G2021 will be possible 😕

Sorry. 

I presume they will just plan for the go ahead like previously .... personally I think it’s too early to say ... so many factors in play here ... although I’m nervous ... the fact that they try to temper expectations makes total sense 

[Sawdusty surfer]

28 minutes ago, parsonjack said:

Probably opening myself for a wave of down votes but after Whitty's somewhat downbeat forecast last night I've woken today with growing doubts that, given the lead time to plan/build etc, G2021 will be possible 😕

Sorry. 

 

15 minutes ago, zahidf said:

Too early to say. And I dont think that sort of speculation is helpful tbh

"A vaccine and drugs are unlikely to materialise until next year and until then some form of social distancing will be required, according to Prof Whitty.

But that certainly doesn't mean all the current restrictions remain in place until then.

Schools, some businesses and public transport might well be reopened in the not too distant future. Pubs and restaurants, under this scenario, will probably be nearer the bottom of the list."

I don't want to appear to be a complete pessimist but from the above quote from Whitty I think that next year's festival could be touch and go especially regarding the lead times involves as @parsonjack quite rightly pointed out. It just isn't possible to leave it until the last minute to call a go/no go. I'm hoping that somehow it can be planned for later in the summer but don't know if that's possible.

The people that I know that are much more involved in the festival than I also have very serious concerns about next year.

Edited April 23, 2020 by Sawdusty Surfer

[Matt42]

12 minutes ago, jparx said:

Must say I'm hugely relieved that Trump PhD has confirmed we won't have a big second peak. What a load off my mind! Back to work I go.

Trump doing it again! Wooo!!

”trump shouts both heads and tails and claims victory wherever it lands”.

Edited April 23, 2020 by Matt42

[zahidf]

11 minutes ago, Sawdusty Surfer said:

 

"A vaccine and drugs are unlikely to materialise until next year and until then some form of social distancing will be required, according to Prof Whitty.

But that certainly doesn't mean all the current restrictions remain in place until then.

Schools, some businesses and public transport might well be reopened in the not too distant future. Pubs and restaurants, under this scenario, will probably be nearer the bottom of the list."

I don't want to appear to be a complete pessimist but from the above quote from Whitty I think that next year's festival could be touch and go especially regarding the lead times involves as @parsonjack quite rightly pointed out. It just isn't possible to leave it until the last minute to call a go/no go. I'm hoping that somehow it can be planned for later in the summer but don't know if that's possible.

The people that I know that are much more involved in the festival than I also have very serious concerns about next year.

Oh I'm all for being realistic but we wont know how the thing will develop. So I think bringing people down isnt helpful at this stage.

[ModernMan]

9 minutes ago, Sawdusty Surfer said:

 

"A vaccine and drugs are unlikely to materialise until next year and until then some form of social distancing will be required, according to Prof Whitty.

But that certainly doesn't mean all the current restrictions remain in place until then.

Schools, some businesses and public transport might well be reopened in the not too distant future. Pubs and restaurants, under this scenario, will probably be nearer the bottom of the list."

I don't want to appear to be a complete pessamist but from the above quote from Whitty I think that next year's festival could be touch and go especially regarding the lead times involves as @parsonjack quite rightly pointed out. It just isn't possible to leave it until the last minute to call a go/no go. I'm hoping that somehow it can be planned for later in the summer but don't know if that's possible.

The people that I know that are much more involved in the festival than I also have very serious concerns about next year.

This is a bummer but all very understandable in the current mindset. I guess all I would say, as a complete non expert in any relevant field, is that there is still a very long time before any decisions have to be made isn’t it? 
 

I don’t think anyone knows where this will be in 6 months time. 

[Crazyfool01]

1 minute ago, zahidf said:

Oh I'm all for being realistic but we wont know how the thing will develop. So I think bringing people down isnt helpful at this stage.

I’m fairness I don’t think it brings anyone down ... it’s just someone’s personal thoughts on wether it will happen at this stage ... I’m sure people have formed there own opinions with or without that post ... 

[Deaf Nobby Burton]

43 minutes ago, parsonjack said:

Probably opening myself for a wave of down votes but after Whitty's somewhat downbeat forecast last night I've woken today with growing doubts that, given the lead time to plan/build etc, G2021 will be possible 😕

Sorry. 

When does the build actually start? They’ve only cancelled this years within the last month, so we’ve got a year from now. With that timeframe the vaccine is to an extent irrelevant, we’ll have significant herd immunity by then anyway. Any current antibody tests put us at 15/20% already, we only need to get to 60%, how could we not be there a year from now? Not to mention the fact that there is a strong suggestion immunity won’t last indefinitely so Corona will become very much like flu, something we live alongside and have to vaccinate against every year anyway. Something that isn’t going away isn’t going to be affecting normal life the same way it is now, a year from now, what would be the point of that? Wrecking our entire way of life to avoid something inevitable 

Edited April 23, 2020 by Deaf Nobby Burton

[zahidf]

2 minutes ago, Deaf Nobby Burton said:

When does the build actually start? They’ve only cancelled this years within the last month, so we’ve got a year from now. With that timeframe the vaccine is to an extent irrelevant, we’ll have significant herd immunity by then anyway. Any current antibody tests put us at 15/20% already, we only need to get to 60%, how could we not be there a year from now? Not to mention the fact that there is a strong suggestion immunity won’t last indefinitely so Corona will become very much like flu, something we live alongside and have to vaccinate against every year anyway. Something that isn’t going away isn’t going to be affecting normal life the same way it is now, a year from now, what would be the point of that? Wrecking our entire way of life to avoid something inevitable 

Some studies say only 3% of the population is infected....

Problem is that mass events aren't necessary in the same way for society to function so banning them would be one way to cope.