I think a greatest hits set could and surely would look different to this one. Stagger Lee, Do You Love Me, There She Goes My Beautiful World, Higgs Boson Blues, Where The Wild Roses Grow. I don't know if he ever plays fifteen feet of pure white snow (have seen him around 10 times since 2013 and haven't heard it) but I really like it. As noted above, the set could benefit from a wee jolt of something in the second half. (I also really like songs like Jesus Alone and Frogs but accept they might not be "greatest hits".)
Regardless, every album since PTSA (which put him in a Pyramid headline "conversation") pushes further away the prospect of a Pyramid headline slot, imo. Putting him on Other vs something pop seems obvious/sensible.
ps I don't think the lyrics appearing on the screen works. I saw Manics and Suede in Leeds millennium square in July and got unintentional giggles at the Manics' sloganeering appearing on the slightly too small screen on the slightly too quiet stage/PA, in broad daylight. Felt briefly like I was in a Louis Theroux subculture documentary.